Product Name :
N-Boc-PEG4-bromide
Description:
N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
1076199-21-7
Molecular Weight:
356.25
Formula:
C13H26BrNO5
Chemical Name:
tert-butyl N-(2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)carbamate
Smiles :
CC(C)(C)OC(=O)NCCOCCOCCOCCBr
InChiKey:
GNDQONYTPMGMTM-UHFFFAOYSA-N
InChi :
InChI=1S/C13H26BrNO5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11H2,1-3H3,(H,15,16)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 1076199-21-7|Molecular Weight: 356.25|Formula: C13H26BrNO5|Chemical Name: tert-butyl N-(2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethyl)carbamate|Smiles: CC(C)(C)OC(=O)NCCOCCOCCOCCBr|InChiKey: GNDQONYTPMGMTM-UHFFFAOYSA-N|InChi: InChI=1S/C13H26BrNO5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11H2,1-3H3,(H,15,16)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (280.{{Curcumin} medchemexpress|{Curcumin} Mitophagy|{Curcumin} Protocol|{Curcumin} In stock|{Curcumin} manufacturer|{Curcumin} Autophagy} 70 mM; ultrasonic and warming and heat to 60°C)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Enterokinase Protein, Human (HEK293, His)} medchemexpress|{Enterokinase Protein, Human (HEK293, His)} Purity & Documentation|{Enterokinase Protein, Human (HEK293, His)} Description|{Enterokinase Protein, Human (HEK293, His)} custom synthesis|{Enterokinase Protein, Human (HEK293, His)} Epigenetics} |Shelf Life: ≥360 days if stored properly.PMID:32970971 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|References:|Jan Anderl, et al. Amatoxin-Conjugates with Improved Linkers. US20130259880A1Products are for research use only. Not for human use.|