Product Name :
JNJ-10397049
Description:
JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R.
CAS:
708275-58-5
Molecular Weight:
484.18
Formula:
C19H20Br2N2O3
Chemical Name:
1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea
Smiles :
CC1(C)OC[C@H](NC(=O)NC2=CC=C(Br)C=C2Br)[C@@H](O1)C1C=CC=CC=1
InChiKey:
RBKIJGLHFFQHBE-IRXDYDNUSA-N
InChi :
InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Anetumab} site|{Anetumab} Inhibitor|{Anetumab} NF-κB|{Anetumab} Biological Activity|{Anetumab} In Vitro|{Anetumab} custom synthesis}
Shelf Life:
≥12 months if stored properly.{{Fluphenazine} web|{Fluphenazine} Anti-infection|{Fluphenazine} Biological Activity|{Fluphenazine} In stock|{Fluphenazine} custom synthesis|{Fluphenazine} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R.|Product information|CAS Number: 708275-58-5|Molecular Weight: 484.18|Formula: C19H20Br2N2O3|Chemical Name: 1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea|Smiles: CC1(C)OC[C@H](NC(=O)NC2=CC=C(Br)C=C2Br)[C@@H](O1)C1C=CC=CC=1|InChiKey: RBKIJGLHFFQHBE-IRXDYDNUSA-N|InChi: InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 170 mg/mL (351.PMID:26644518 11 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|JNJ-10397049 (10-30 mg/kg) decreases the latency for persistent sleep and increased nonrapid eye movement and rapid eye movement sleep time. JNJ-10397049 blocks ethanol self-administration, place preference and reinstatement.|Products are for research use only. Not for human use.|