Product Name :
Nav1.1 activator 1
Description:
Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6.
CAS:
2332897-85-3
Molecular Weight:
440.46
Formula:
C24H23F3N4O
Chemical Name:
4-(2,5-difluorophenyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-N-[6-(propan-2-yl)pyridin-3-yl]pyridine-3-carboxamide
Smiles :
CC(C)C1=CC=C(C=N1)NC(=O)C1C(=NC=CC=1C1=CC(F)=CC=C1F)N1C[C@@H](F)CC1
InChiKey:
HRGJTEFGFUJXIF-INIZCTEOSA-N
InChi :
InChI=1S/C24H23F3N4O/c1-14(2)21-6-4-17(12-29-21)30-24(32)22-18(19-11-15(25)3-5-20(19)27)7-9-28-23(22)31-10-8-16(26)13-31/h3-7,9,11-12,14,16H,8,10,13H2,1-2H3,(H,30,32)/t16-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6.|Product information|CAS Number: 2332897-85-3|Molecular Weight: 440.46|Formula: C24H23F3N4O|Chemical Name: 4-(2,5-difluorophenyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-N-[6-(propan-2-yl)pyridin-3-yl]pyridine-3-carboxamide|Smiles: CC(C)C1=CC=C(C=N1)NC(=O)C1C(=NC=CC=1C1=CC(F)=CC=C1F)N1C[C@@H](F)CC1|InChiKey: HRGJTEFGFUJXIF-INIZCTEOSA-N|InChi: InChI=1S/C24H23F3N4O/c1-14(2)21-6-4-17(12-29-21)30-24(32)22-18(19-11-15(25)3-5-20(19)27)7-9-28-23(22)31-10-8-16(26)13-31/h3-7,9,11-12,14,16H,8,10,13H2,1-2H3,(H,30,32)/t16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (567.{{Dipyridamole} site|{Dipyridamole} Apoptosis|{Dipyridamole} Technical Information|{Dipyridamole} Data Sheet|{Dipyridamole} custom synthesis|{Dipyridamole} Epigenetic Reader Domain} 59 mM; Need ultrasonic).{{DOTATATE} web|{DOTATATE} Protocol|{DOTATATE} Purity|{DOTATATE} supplier|{DOTATATE} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23996047 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Nav1.1 activator 1 (compound 4) is a valuable Nav1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome.|Products are for research use only. Not for human use.|