Product Name :
PHCCC
Description:
PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.
CAS:
179068-02-1
Molecular Weight:
294.30
Formula:
C17H14N2O3
Chemical Name:
(6E)-6-(hydroxyimino)-N-phenyl-2-oxatricyclo[5.4.0.0³,⁵]undeca-1(11),7,9-triene-3-carboxamide
Smiles :
O/N=C1\C2CC2(OC2=CC=CC=C2\1)C(=O)NC1C=CC=CC=1
InChiKey:
FPXPIEZPAXSELW-CYVLTUHYSA-N
InChi :
InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{CCCP} site|{CCCP} Mitochondrial Metabolism|{CCCP} Purity & Documentation|{CCCP} Data Sheet|{CCCP} supplier|{CCCP} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.|Product information|CAS Number: 179068-02-1|Molecular Weight: 294.30|Formula: C17H14N2O3|Chemical Name: (6E)-6-(hydroxyimino)-N-phenyl-2-oxatricyclo[5.4.0.0³,⁵]undeca-1(11),7,9-triene-3-carboxamide|Smiles: O/N=C1\C2CC2(OC2=CC=CC=C2\1)C(=O)NC1C=CC=CC=1|InChiKey: FPXPIEZPAXSELW-CYVLTUHYSA-N|InChi: InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 12.{{NAPQI} site|{NAPQI} Metabolic Enzyme/Protease|{NAPQI} Purity & Documentation|{NAPQI} Data Sheet|{NAPQI} custom synthesis|{NAPQI} Autophagy} 5 mg/mL (42.PMID:35670838 47 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.|In Vivo:|PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.|Products are for research use only. Not for human use.|