tudy populationThe study was a retrospective evaluation of information acquired from dementia and control elderly patients older than 60 years from January 2016 and December 2018 who had been treated in our hospital. Patients with suspected dementia diagnosis had been transferred from neurology, geriatrics, or other departments (20 ) or admitted for hospitalization and remedy resulting from acute illness and had been subsequently diagnosed with dementia (70 ) or have been diagnosed with dementia and the situation aggravated to moderate and severe (10 ). The manage CDK7 Inhibitor Gene ID individuals received therapy for a quantity of other situations. Exclusion criteria have been people with liver failure, a serum creatinine concentration 120 mol/L, hyperthyroidism or hypothyroidism, problems with the immune method, or on drugs that alter cholesterol, low-density lipoprotein cholesterol (LDL-C), and highdensity lipoprotein cholesterol (HDL-C) concentrations. The diagnosis of dementia was created based on the 2018 Chinese suggestions for diagnosis and management of dementia and cognitive impairment (I): dementia classification and diagnostic (Zhonghua Xue, 2018). The Institutional Review Board authorized the employed protocols and waived the requirement for written informed consent.2.Data collectionWe reviewed the medical histories of individuals and documented age, gender, comorbidities, and serum parameters (fasting blood glucose, FBG (mmol/L); HbA1C (mg/dL); total cholesterol, TC (mmol/L); LDL-C (mmol/L); HDL-C (mmol/L); HCY (mol/L); folic acid (mmol/L); vitamin D2 (mmol/L); and vitamin D3 (mmol/L)). Cardiac disease was defined as a history of congestive heart failure; myocardial infarction; angina pectoris or medication with digitalis at any time; hypertension, systolic blood stress 140 mmHg or diastolic blood pressure 90 mmHg; use of antihypertensive agents. Diabetes refers to fasting glucose concentration 7 mmol/L, postprandial glucose or even a two h 75 g oral glucoseGONG ET AL .three ofpostloaded level 1 mmol/L, insulin, or oral hypoglycemic medication. Hypercholesterolemia refers to fasting TC six.2 mmol/L or the use of lipid-lowering drugs (statins, fibrate, bile acid sequestrant). Respiratory problems refer to asthma, COPD, bronchiectasis, pulmonary fibrosis, or sarcoidosis. Cerebrovascular illness refers to stroke, transient ischemic attacks, aneurysm, or vascular malformations. The history of gastrointestinal issues refers to the esophagus, stomach, small CYP2 Inhibitor drug intestine, substantial intestine, rectum, pancreas, gallbladder, and liver. Nephrosis was defined as a urine test constructive for protein, a blood test good for protein levels reduced than standard, and the clinical detection of edema. A history of fracture was defined as a break in any bone or cartilage. Tumor was defined as obtaining a prior healthcare history of tumors.TA B L EGeneral traits from the patientsPatients (n = 4722) Male Female 2479 (52.5) 2243 (47.5) 73.0 15.5 Neurology Geriatrics 3672 (77.8) 1050 (22.two) 565 (12.0) 4157 (88.0) 3502 (74.2) 2811 (59.5) 1839 (38.9) 1192 (25.two) 1123 (23.8) 319 (6.8) 206 (four.4) 84 (1.eight) 84 (1.eight) 10 (0.2) five.9 2.5 six.three 1.3 4.3 1.1 1.2 0.three two.3 0.eight 17.2 ten.5 8.five 5.0 1.7 3.3 14.1 eight.Variables GenderAge Healthcare departmentDiagnosisDementia NondementiaComorbiditiesCerebrovascular issues Hypertension Cardiac disorders2.Measurements of serum indicatorsDiabetes Respiratory disordersFasting venous blood samples (three and four mL) have been collected into tubes containing ethylenediaminetetraacetic acid (EDTA)-K2 anticoa
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