Hritis Rheum. 40, 1612?04 (1997). two. Cho, J. H. Feldman, M. Heterogeneity of autoimmune

Hritis Rheum. 40, 1612?04 (1997). two. Cho, J. H. Feldman, M. Heterogeneity of autoimmune ailments: pathophysiologic insights from genetics and implications for new therapies. Nat. Med. 21, 730?38 (2015). 3. Ruffatti, A. et al. Anti-double-stranded DNA antibodies within the healthier elderly: prevalence and characteristics. J. Clin. Immunol. 10, 300?03 (1990). four. Rubin, R. L., Teodorescu, M., Beutner, E. H. Plunkett, R. W. Complement-fixing properties of antinuclear antibodies distinguish drug-induced lupus from systemic lupus Respiratory Inhibitors Reagents erythematosus. Lupus 13, 249?56 (2004). five. DeGiorgio, L. A., Konstantinov, K. N. Diamond, B. A subset of lupus anti-DNA antibodies cross-reacts using the NR2 glutamate receptor in systemic lupus erythematosus. Nat. Med. 7, 1189?193 (2001). six. Sun, K.-H., Yu, C.-L., Tang, S.-J. Sun, G.-H. Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1, IL-6, IL-8, IL-10 and TNF- from regular human mononuclear cells involving in the lupus pathogenesis. Immunology 99, 352?60 (2000). 7. Sprangers, B., Monahan, M. Appel, G. B. Diagnosis and therapy of lupus nephritis flares – an update. Nat. Rev. Nephrology eight, 709?17 (2012). eight. Lau, C. S. Mak, A. The socioeconomic burden of SLE. Nat. Rev. Rheumatol. five, 400?04 (2009). 9. Pisetsky, D. S. Anti-DNA antibodies – quintessential biomarkers of SLE. Nat. Rev. Rheumatol. 12, 102?10 (2016). 10. Liu, C. C., Kao, A. H., Manzi, S. Ahearn, J. M. Biomarkers in systemic lupus erythematosus: challenges and prospects for the future. Ther. Adv. Musculoskelet. Dis. 5, 210?33 (2013). 11. Welsh, R. Vyska, K. Phosphopeptides in extremely purified calf thymusDNA. Standard Appl. Histochem. 31, 281?98 (1987). 12. Porsch, B., Laga, R., Horsk? J., Ko , C. Ulbrich, K. Molecular weight and polydispersity of calf-thymus DNA: static light-scattering and size-exclusion chromatography with dual detection. Biomacromolecules 10, 3148?150 (2009). 13. Sanguineti, S. et al. Certain recognition of a DNA immunogen by its elicited antibody. J. Mol. Biol. 370, 183?95 (2007). 14. Stevens, S. Y., Swanson, P. C., Voss, E. W. Jr. Glick, G. D. Evidence for induced match in antibody-DNA complexes. J. Am. Chem. Soc. 115, 1585?586 (1993). 15. Barbas, S. M., Ghazal, P., Barbas, C. F. III Burton, D. R. Recognition of DNA by synthetic antibodies. J. Am. Chem. Soc. 116, 2161?162 (1994). 16. Tran, T. N. et al. A universal DNA-based protein detection Adenine Receptors Inhibitors Reagents program. J. Am. Chem. Soc. 135, 14008?4011 (2013). 17. An, Y., Raju, R. K., Lu, T. Wheeler, S. E. Aromatic interactions modulate the 5-base selectivity of the DNA-binding autoantibody ED-10. J. Phys. Chem. B 118, 5653?659 (2014). 18. Chiaro, T. R., Davis, K. W., Wilson, A., Suh-Lailam, B. Tebo, A. E. Evaluation of a higher avidity anti-dsDNA IgG enzyme-linked immunosorbent assay for the diagnosis of systemic lupus erythematosus. Clin. Chim. Acta 412, 1076?080 (2011). 19. Pavlovic, M. et al. Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE. Autoimmune Dis. 2010, Article ID462841 (2010). 20. Fernando, H., Rodriguez, R. Balasubramanian, S. Selective recognition of a DNA G-quadruplex by an engineered antibody. Biochemistry 47, 9365?371 (2008). 21. Brunner, H. I., Huggins, J. Klein-Gitelman, M. S. Pediatric SLE – towards a extensive management program. Nat. Rev. Rheumatol. 7, 225?33 (2011). 22. Samuelsen, S. V. et al. Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease particular antibodies. Sci. Rep. six, 35827 (2016).