Rt were greater than in PsA (P = 0.017). There was a significant
Rt were greater than in PsA (P = 0.017). There was a significant correlation PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28914615 between IMT and age in the RA cohort. However, mean age in the three groups was not different and no correlation between IMT and age was seen in either the PsA or the control group. The area under the curve (AUC) ESR correlated with the AUC CRP in the group as a whole and in both RA and PsA separately. No correlation was found between the AUC for ESR or CRP PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25636517 and IMT in the different subgroups or in patients with an increased IMT. Conclusions Patients with inflammatory arthritis (RA > PsA) are at a greater risk of developing atherosclerosis compared with control subjects. No correlation has been found to date between IMT values and the burden of inflammation as measured by ESR and CRP over time. Some additional mechanism of accelerated atherosclerosis in inflammation, yet to be determined, may well apply. The results are preliminary and recruitment with additional analysis is ongoing.P16 Altered composition of CD97 splice variants in rheumatoid synovial tissueFA van Gaalen1, TCTM van der Pouw Kraan2, RGHH Nelissen3, TWJ Huizinga1, CL Verweij2 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; 2Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands; 3Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands Arthritis Res Ther 2005, 7(Suppl 1):P16 (DOI 10.1186/ar1537) The intimal lining of synovial tissue consists of fibroblast-like synoviocytes (type A synoviocytes) and macrophages (type B synoviocytes). These cells are able to interact through the CD97/CD55 receptor ligand system. The CD97 receptor is a heterodimer receptor composed of an alpha and a beta subunit. The CD97alpha subunit may exist as three isoforms due to alternative spliced transcripts, each having a different affinity for CD55. When comparing synovium of rheumatoid arthritis (RA) patients with synovium of patients with osteoarthritis (OA), no increase in the level of total of CD97alpha or in the level of CD97beta transcripts was found. However, in RA synovium a relative increased expression of CD97 transcripts encoding isoforms with an increased affinity for CD55 (CD97alpha2 and CD97alpha3 mRNA) was detected. A difference in CD97 splice variants between RA and OA tissues could not be attributed to differences in composition of cells as in both tissues the majority of CD97+ cells were CD14+ macrophages/monocytes — 93 in RA and 94 in OA, respectively. These data indicate that during inflammation CD97 splicing is regulated, and we propose that this is likely to affect trafficking and Necrostatin-1 cost functioning of CD97-positive leukocytes.with inflammation and associated with reduced thymic activity as measured by T-cell recepter excision circle (TREC) content. However, it is still not clear whether these dysfunctions are a primary feature of RA or only secondary to inflammation. Therefore we analysed RA patients in clinical remission in whom systemic inflammation was controlled. Methods Patients were defined as `in remission’ when they had controlled disease, with no change of activity for at least 6 months, C-reactive protein below 15, no swollen or tender joints and on stable treatment (with or without therapy). Measurements of TREC content in CD4+ T cells was by real-time PCR. IL-7 quantification was by ELISA. Proliferation assay in response to mitogen, IL-2, TCR stimulation or recall antigen. Res.