Ransferase NF-B: Nuclear factor kappa B NQO1: NAD(P)H: quinone

Ransferase NF-B: Nuclear factor kappa B NQO1: NAD(P)H: quinone oxidoreductase 1 NOX: NADPH-oxidase Nrf1/2: Nuclear factor E2-related factor 1/2 P-gp: P-glycoprotein PPI3K: Phosphoinositol-3-kinase PKC: Protein kinase C PM: Poor Metabolisers ABC: AhR: Akt: AP-1: ARE: Bcl2: BCRP: CAT: COMT: CYP: EM: FLIP:Oxidative AKB-6548 solubility Medicine and Cellular Longevity Prx: RNS: ROS: SNP: SOD: STAT3: Peroxiredoxins Reactive nitrogen species Reactive oxygen species Single nuclear polymorphism Superoxide dismutase Signal transducer and activator of transcription 3 SULT1A1/A3: Sulfotransferases A1/A3 TNF: Tumour necrosis factor alpha TLR: LOR-253 web Toll-like receptor Trx: Thioredoxin TrxR: Thioredoxin reductase UGT: UDP-glucuronosyltransferase UM: Ultrarapid Metabolisers XRE: Xenobiotic responsive elements.cytochrome P450 super-family in human extrahepatic tissues,” Current Drug Metabolism, vol. 9, no. 2, pp. 129?43, 2008. D. Kluth, A. Banning, I. Paur, R. Blomhoff, and R. BrigeliusFloh? “Modulation of pregnane X receptor- and electrophile e responsive element-mediated gene expression by dietary polyphenolic compounds,” Free Radical Biology and Medicine, vol. 42, no. 3, pp. 315?25, 2007. K. W. Bock and C. K?hle, “Coordinate regulation of drug o metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters,” Drug Metabolism Reviews, vol. 36, no. 3-4, pp. 595?15, 2004. C. D. Klaassen and A. L. Slitt, “Regulation of hepatic transporters by xenobiotic receptors,” Current Drug Metabolism, vol. 6, no. 4, pp. 309?28, 2005. T. Nguyen, P. J. Sherratt, and C. B. Pickett, “Regulatory mechanisms controlling gene expression mediated by the antioxidant response element,” Annual Review of Pharmacology and Toxicology, vol. 43, pp. 233?60, 2003. A. K. Jaiswal, “Nrf2 signaling in coordinated activation of antioxidant gene expression,” Free Radical Biology and Medicine, vol. 36, no. 10, pp. 1199?207, 2004. B. Fadeel and S. Orrenius, “Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease,” Journal of Internal Medicine, vol. 258, no. 6, pp. 479?17, 2005. a L. G?th, P. Rass, and A. P , “Catalase enzyme mutations and o their association with diseases,” Molecular Diagnosis, vol. 8, no. 3, pp. 141?49, 2004. J. G. Scandalios, “Oxidative stress: Molecular perception and transduction of signals triggering antioxidant gene defenses,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 7, pp. 995?014, 2005. A. Bindoli and M. P. Rigobello, “Principles in redox signaling: from chemistry to functional significance,” Antioxidants Redox Signaling, vol. 18, no. 13, pp. 1557?593, 2013. A. Ayala, M. F. Mu oz, and S. Arg?elles, “Lipid peroxidation: n u production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 360438, 31 pages, 2014. C. M. Cabello, W. B. Bair III, and G. T. Wondrak, “Experimental therapeutics: targeting the redox Achilles heel of cancer,” Current Opinion in Investigational Drugs, vol. 8, no. 12, pp. 1022?1037, 2007. G. T. Wondrak, “Redox-directed cancer therapeutics: molecular mechanisms and opportunities,” Antioxidants and Redox Signaling, vol. 11, no. 12, pp. 3013?069, 2009. L. G. Korkina, S. Pastore, C. De Luca, and V. A. Kostyuk, “Metabolism of plant polyphenols in the skin: beneficial versus deleterious effects,” Current Drug Metabolism, vol. 9, no. 8, pp. 710?29, 2008. F. Oesch, E. Fabian, B. Oesch-.Ransferase NF-B: Nuclear factor kappa B NQO1: NAD(P)H: quinone oxidoreductase 1 NOX: NADPH-oxidase Nrf1/2: Nuclear factor E2-related factor 1/2 P-gp: P-glycoprotein PPI3K: Phosphoinositol-3-kinase PKC: Protein kinase C PM: Poor Metabolisers ABC: AhR: Akt: AP-1: ARE: Bcl2: BCRP: CAT: COMT: CYP: EM: FLIP:Oxidative Medicine and Cellular Longevity Prx: RNS: ROS: SNP: SOD: STAT3: Peroxiredoxins Reactive nitrogen species Reactive oxygen species Single nuclear polymorphism Superoxide dismutase Signal transducer and activator of transcription 3 SULT1A1/A3: Sulfotransferases A1/A3 TNF: Tumour necrosis factor alpha TLR: Toll-like receptor Trx: Thioredoxin TrxR: Thioredoxin reductase UGT: UDP-glucuronosyltransferase UM: Ultrarapid Metabolisers XRE: Xenobiotic responsive elements.cytochrome P450 super-family in human extrahepatic tissues,” Current Drug Metabolism, vol. 9, no. 2, pp. 129?43, 2008. D. Kluth, A. Banning, I. Paur, R. Blomhoff, and R. BrigeliusFloh? “Modulation of pregnane X receptor- and electrophile e responsive element-mediated gene expression by dietary polyphenolic compounds,” Free Radical Biology and Medicine, vol. 42, no. 3, pp. 315?25, 2007. K. W. Bock and C. K?hle, “Coordinate regulation of drug o metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters,” Drug Metabolism Reviews, vol. 36, no. 3-4, pp. 595?15, 2004. C. D. Klaassen and A. L. Slitt, “Regulation of hepatic transporters by xenobiotic receptors,” Current Drug Metabolism, vol. 6, no. 4, pp. 309?28, 2005. T. Nguyen, P. J. Sherratt, and C. B. Pickett, “Regulatory mechanisms controlling gene expression mediated by the antioxidant response element,” Annual Review of Pharmacology and Toxicology, vol. 43, pp. 233?60, 2003. A. K. Jaiswal, “Nrf2 signaling in coordinated activation of antioxidant gene expression,” Free Radical Biology and Medicine, vol. 36, no. 10, pp. 1199?207, 2004. B. Fadeel and S. Orrenius, “Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease,” Journal of Internal Medicine, vol. 258, no. 6, pp. 479?17, 2005. a L. G?th, P. Rass, and A. P , “Catalase enzyme mutations and o their association with diseases,” Molecular Diagnosis, vol. 8, no. 3, pp. 141?49, 2004. J. G. Scandalios, “Oxidative stress: Molecular perception and transduction of signals triggering antioxidant gene defenses,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 7, pp. 995?014, 2005. A. Bindoli and M. P. Rigobello, “Principles in redox signaling: from chemistry to functional significance,” Antioxidants Redox Signaling, vol. 18, no. 13, pp. 1557?593, 2013. A. Ayala, M. F. Mu oz, and S. Arg?elles, “Lipid peroxidation: n u production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 360438, 31 pages, 2014. C. M. Cabello, W. B. Bair III, and G. T. Wondrak, “Experimental therapeutics: targeting the redox Achilles heel of cancer,” Current Opinion in Investigational Drugs, vol. 8, no. 12, pp. 1022?1037, 2007. G. T. Wondrak, “Redox-directed cancer therapeutics: molecular mechanisms and opportunities,” Antioxidants and Redox Signaling, vol. 11, no. 12, pp. 3013?069, 2009. L. G. Korkina, S. Pastore, C. De Luca, and V. A. Kostyuk, “Metabolism of plant polyphenols in the skin: beneficial versus deleterious effects,” Current Drug Metabolism, vol. 9, no. 8, pp. 710?29, 2008. F. Oesch, E. Fabian, B. Oesch-.