vH RAS Antibody Summary
| Immunogen |
This HRAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-176 amino acids from the C-terminal region of human HRAS.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
HRAS
|
| Purity |
Ammonium sulfate precipitation
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Reacts with Human and Mouse. Predicted to react with Chicken and Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Ammonium sulfate precipitation
|
Alternate Names for vH RAS Antibody
- C-BAS/HAS
- C-HA-RAS1
- c-has/bas p21 protein
- C-H-RAS
- c-ras-Ki-2 activated oncogene
- CTLO
- GTP- and GDP-binding peptide B
- GTPase HRas
- HAMSV
- ha-Ras
- Ha-Ras1 proto-oncoprotein
- HRAS1
- H-Ras-1
- H-RASIDX
- K-RAS
- N-RAS
- p19 H-RasIDX protein
- p21ras
- Ras family small GTP binding protein H-Ras
- RASH1
- transformation gene: oncogene HAMSV
- Transforming protein p21
- v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Background
This gene belongs to the Ras oncogene family, whosemembers are related to the transforming genes of mammalian sarcomaretroviruses. The products encoded by these genes function insignal transduction pathways. These proteins can bind GTP and GDP,and they have intrinsic GTPase activity. This protein undergoes acontinuous cycle of de- and re-palmitoylation, which regulates itsrapid exchange between the plasma membrane and the Golgi apparatus.Mutations in this gene cause Costello syndrome, a diseasecharacterized by increased growth at the prenatal stage, growthdeficiency at the postnatal stage, predisposition to tumorformation, mental retardation, skin and musculoskeletalabnormalities, distinctive facial appearance and cardiovascularabnormalities. Defects in this gene are implicated in a variety ofcancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, whichencode different isoforms, have been identified for this gene.