p57 Kip2 Antibody Summary
| Immunogen |
A synthetic peptide from human p57Kip2 protein. NP_001116103
|
| Specificity |
This antibody reacts with a 57 kD protein.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CDKN1C
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Cow, Mouse
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
No buffer
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for p57 Kip2 Antibody
- Beckwith-Wiedemann syndrome
- BWS
- cyclin-dependent kinase inhibitor 1C (p57, Kip2)
- cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase inhibitor p57
- KIP2BWCR
- p57
- p57Kip2
- WBS
Background
p57Kip2 protein is a inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 protein is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilms tumor and Beckwith-Wiedemann syndrome. Its binding is cyclin dependent. Overexpression of the protein arrests cells in G1. KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye. Most of the KIP2-expressing cells are terminally differentiated, suggesting that it is involved in decisions to exit the cell cycle during development and differentiation. It is located at 11p15.5, a region implicated in sporadic cancers and Beckwith-Wiedemann syndrome, P57 kip2 is a familial cancer syndrome, marking it as a candidate tumor suppressor. Alternate splicing of this gene generates several transcript variants encoding two different isoforms.