p27/Kip1 Antibody Summary
| Immunogen |
Peptide with sequence C-EQTPKKPGLRRRQT corresponding to C-Terminus according to NP_004055.1.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CDKN1B
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IP: An anonymous customer has reported usage under native conditions. WB: Approx. 26-27 kDa band observed in human breast and prostate lysates is reported in scientific literature (PMID: 16169901).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Bovine, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for p27/Kip1 Antibody
- CDKN1B
- CDKN4
- cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor p27
- Kip1
- KIP1P27KIP1
- MEN1B
- MEN4
- p27
- p27Kip1
Background
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.