p23/PTGES3 Antibody (3H1-2A8) Summary
| Immunogen |
TEBP (AAH03005, 1 a.a. ~ 161 a.a) full length recombinant protein with GST tag.MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
|
| Localization |
Cytoplasmic
|
| Specificity |
PTGES3 – unactive progesterone receptor, 23 kD
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PTGES3
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
|
Reactivity Notes
Human. Other species not tested.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for p23/PTGES3 Antibody (3H1-2A8)
- CPGES
- cPGESp23
- Cytosolic prostaglandin E2 synthase
- Hsp90 co-chaperone
- p23
- P23cytosolic prostaglandin E synthase
- Progesterone receptor complex p23
- prostaglandin E synthase 3 (cytosolic)
- prostaglandin E synthase 3
- PTGES3
- TEBP
- TEBPEC 5.3.99.3
- Telomerase-binding protein p23
- unactive progesterone receptor, 23 kD
Background
p23 is a 23kDa ubiquitous, highly conserved co-chaperone for Hsp90. p23 binds Hsp90 and participates in the folding of a number of cell regulatory proteins. p23 is thought to modulate Hsp90 activity in the last stages of the chaperoning pathway and only binds Hsp90 that is in turn bound to ATP which stablizes this state of Hsp90. p23 is a prominent target in leukemic cell apoptosis and may be an important target for antileukemic treatment. Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP 70 and HSP 90), immunosuppressant binding proteins called immunophilins (the FK 506 binding proteins, FKBP 52 & FKBP 54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP 70, HSP 90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP 90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.