p21/CIP1/CDKN1A Antibody (SPM306) [DyLight 405] Summary
| Immunogen |
Human recombinant p21 protein
|
| Localization |
Nuclear
|
| Specificity |
This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CDKN1A
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Notes
Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for p21/CIP1/CDKN1A Antibody (SPM306) [DyLight 405]
- CAP20cyclin-dependent kinase inhibitor 1
- CDK-interacting protein 1
- CDKN1A
- CDKN1melanoma differentiation associated protein 6
- CIP1
- CIP1WAF1CDK-interaction protein 1
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- MDA6
- MDA-6
- Melanoma differentiation-associated protein 6
- p21
- p21CIP1
- p21Cip1/Waf1
- PIC1
- SDI1DNA synthesis inhibitor
- wild-type p53-activated fragment 1