hnRNP C1 + C2 Antibody

Product: GDC-0340

hnRNP C1 C2 Antibody Summary

Immunogen
Synthetic peptides corresponding to HNRNPC(heterogeneous nuclear ribonucleoprotein C (C1/C2)) The peptide sequence was selected from the middle region of HNRNPC.Peptide sequence ESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSAN.
Clonality
Polyclonal
Host
Rabbit
Gene
HNRNPC
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This is a rabbit polyclonal antibody against HNRNPC and was validated on Western blot.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS & 2% Sucrose.
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for hnRNP C1 C2 Antibody

  • C1
  • C2
  • heterogeneous nuclear ribonucleoprotein C (C1/C2)
  • heterogeneous nuclear ribonucleoproteins C1/C2
  • hnRNP C1/C2
  • HNRNP
  • hnRNPC
  • HNRPC
  • MGC104306
  • MGC105117
  • MGC117353
  • MGC131677
  • nuclear ribonucleoprotein particle C1 protein
  • nuclear ribonucleoprotein particle C2 protein
  • SNRPC

Background

This protein is associated with pre-mRNAs in the nucleus and appears to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein acts as a tetramer and is involved in the assembly of 40S hnRNP particles. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.

PMID: 19236003