c-jun [p Thr91] Antibody (C-J 4C4/1) Summary
| Immunogen |
C-Jun phosphorylated at T91 and T93
|
| Modification |
p Thr91
|
| Localization |
Nuclear
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
JUN
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A or G purified
|
Notes
Positive control(s): NIH 3T3 cells treated with UV or anisomycin for 1 hour..
Alternate Names for c-jun [p Thr91] Antibody (C-J 4C4/1)
- Activator protein 1
- AP1
- AP-1
- cJun
- c-Jun
- enhancer-binding protein AP1
- Jun activation domain binding protein
- jun oncogene
- jun proto-oncogene
- JUN
- Proto-oncogene c-Jun
- transcription factor AP-1
- V-jun avian sarcoma virus 17 oncogene homologp39
- v-jun sarcoma virus 17 oncogene homolog (avian)
- v-jun sarcoma virus 17 oncogene homolog
Background
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.