Product: Impurity C of Calcitriol
beta 2-Microglobulin Antibody (BBM.1) Summary
| Immunogen |
MOLT-4 human T cell line
|
| Localization |
Cell Surface and Extracellular (Secreted)
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| Marker |
Renal Failure & Tumor Marker
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| Specificity |
Recognizes a protein of 12kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
B2M
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
Hu-chromosome location: 15q21-q22.2
Immunohistochemistry-Frozen 0.5 – 1 ug/ml for 30 minutes at RT. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| Theoretical MW |
12 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for beta 2-Microglobulin Antibody (BBM.1)
- B2M
- beta 2Microglobulin
- beta 2-Microglobulin
- beta chain of MHC class I molecules
- beta-2-microglobin
- beta-2-microglobulin