alpha-Galactosidase A/GLA Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Galactosidase alpha. The exact sequence is proprietary.
|
| Localization |
Lysosome
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
GLA
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (80%), Cow (81%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0) and 20% Glycerol
|
| Preservative |
0.025% Proclin 300
|
| Concentration |
0.157 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for alpha-Galactosidase A/GLA Antibody
- agalsidase alfa
- Agalsidase alpha
- Agalsidase
- Alpha-D-galactosidase A
- alpha-D-galactoside galactohydrolase 1
- Alpha-D-galactoside galactohydrolase
- alpha-gal A
- alpha-galactosidase A
- EC 3.2.1
- EC 3.2.1.22
- GALA
- galactosidase, alpha
- GLA
- Melibiase
Background
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq]