XPD Antibody (4G2-2A6) Summary
| Immunogen |
ERCC2 (AAH08346, 1 a.a. – 405 a.a.) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGQAQHCGSSRNQKRSHP
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| Specificity |
ERCC2 – excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
ERCC2
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody reactivity against cell lysate and recombinant protein for WB. It has been used for ELISA. ChIP usage reported in scientific literature (PMID: 24609361).
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for XPD Antibody (4G2-2A6)
- Basic transcription factor 2 80 kDa subunit
- BTF2 p80
- COFS2
- CXPD
- DNA excision repair protein ERCC-2
- DNA repair protein complementing XP-D cells
- EC 3.6.1
- EC 3.6.4.12
- EM9
- EM9TFIIH basal transcription factor complex 80 kDa subunit
- ERCC2
- excision repair cross-complementing rodent repair deficiency, complementationgroup 2
- MAG
- MGC102762
- MGC126218
- MGC126219
- TFIIH 80 kDa subunit
- TFIIH basal transcription factor complex helicase subunit
- TFIIH basal transcription factor complex helicase XPD subunit
- TTD
- xeroderma pigmentosum complementary group D
- Xeroderma pigmentosum group D-complementing protein
- XPD
- XPDC
- XPDTFIIH p80
Background
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome.