XPC Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 890 and 940 of human xeroderma pigmentosum, complementation group C using the numbering given in entry NP_004619.2 (GeneID 7508).
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| Predicted Species |
Canine (100%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
XPC
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating macaque and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
TBS and 0.1% BSA
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for XPC Antibody
- complementation group C antibody
- p125
- RAD4
- Xeroderma pigmentosum group C-complementing protein
- xeroderma pigmentosum, complementation group C
- XP3
- XPCCDNA repair protein complementing XP-C cells
Background
Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC); also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.