Product: AMG 489 (S-enantiomer)
Vav-1 Antibody (3A11) Summary
| Immunogen |
VAV1 (AAH13361, 681 a.a. – 790 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. RGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC
|
| Specificity |
VAV1 – vav 1 oncogene (3A11)
|
| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
VAV1
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF and ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Vav-1 Antibody (3A11)
- oncogene vav
- proto-oncogene vav
- vav 1 guanine nucleotide exchange factor
- vav proto-oncogene
- Vav1
- Vav-1
- vav-T
- VAVvav 1 oncogene
Background
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.