Product: Mebeverine metabolite Mebeverine alcohol
VCAM-1/CD106 Antibody (MR106) [Biotin] Summary
| Immunogen |
The immunogen for this antibody was CD106.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
VCAM1
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This MR106 antibody has been tested by flow cytometric analysis of rat bone marrow cells. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
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| Readout System |
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Reactivity Notes
This antibody is reactive to Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for VCAM-1/CD106 Antibody (MR106) [Biotin]
- CD106 antigen
- CD106
- DKFZp779G2333
- INCAM-100
- L1CAM
- MGC99561
- vascular cell adhesion molecule 1
- vascular cell adhesion protein 1
- V-CAM 1
- VCAM1
- VCAM-1
Background
The MR106 monoclonal antibody reacts with rat CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and further upregulate VCAM-1 upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin alpha4beta7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.