ULK1 Antibody (2H8) Summary
| Immunogen |
ULK1 (NP_003556.1 602 a.a. – 715 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPG
|
| Specificity |
ULK1 – unc-51-like kinase 1 (C. elegans)
|
| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ULK1
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for ULK1 Antibody (2H8)
- ATG1 autophagy related 1 homolog
- ATG1
- ATG1A
- EC 2.7.11
- EC 2.7.11.1
- FLJ38455
- FLJ46475
- KIAA0722
- serine/threonine-protein kinase ULK1
- unc-51 (C. elegans)-like kinase 1
- UNC51
- Unc51.1
- unc-51-like kinase 1 (C. elegans)
- Unc-51-like kinase 1
Background
ULK1 belongs to the serine/threonine protein kinase family. It is involved in axon growth and plays an essential role in neurite branching during sensory axon outgrowth. Knockdown of ULK1 results in impaired endocytosis of nerve growth factor (NGF), excessive axon arborization, and severely stunted axon elongation indicating that ULK1 mediates a non-clathrin-coated endocytosis in sensory growth cones. Knockdown of ULK1 also inhibits the autophagic response. It appears to act as a convergence point for multiple signals that regulate autophagy, and in turn interacts with a large number of autophagy-related (Atg) proteins.