Product: α-Tocopherol (phosphate)
UBTF Antibody Summary
| Immunogen |
The antiserum was produced against synthesized peptide derived from human UBF1. The immunogen region is: Internal.
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| Specificity |
UBF1 Antibody detects endogenous levels of total UBF1 protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
UBTF
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human,Mouse, Rat
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for UBTF Antibody
- 90-KDa Nucleolus Organizer Region Autoantigen
- Autoantigen NOR-90
- NOR-90
- nucleolar transcription factor 1
- UBF
- UBF1
- UBF-1
- UBF2
- UBFUBF-1
- upstream binding transcription factor, RNA polymerase I
- Upstream-binding factor 1
Background
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or TAFs). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM]