UBR1 Antibody (2F5)

Product: KN-63

UBR1 Antibody (2F5) Summary

Immunogen
UBR1 (NP_777576, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag.ADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCG
Specificity
UBR1 – ubiquitin protein ligase E3 component n-recognin 1
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
UBR1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA 1:100-1:2000
Application Notes
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
Publications
Read Publications using H00197131-M01.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for UBR1 Antibody (2F5)

  • E3 ubiquitin-protein ligase UBR1
  • E3a ligase
  • EC 6.3.2.-
  • JBS
  • MGC142065
  • MGC142067
  • N-recognin-1
  • ubiquitin ligase E3 alpha-I
  • ubiquitin protein ligase E3 component n-recognin 1
  • ubiquitin-protein ligase E3-alpha
  • Ubiquitin-protein ligase E3-alpha-1
  • Ubiquitin-protein ligase E3-alpha-I

Background

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

PMID: 8112384