Tie-2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human TIE2. The exact sequence is proprietary.
|
| Localization |
Membrane; Single-pass type I membrane protein
|
| Predicted Species |
Rat (98%), Bovine (99%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
TEK
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
126 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Zebrafish (81%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.54 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Tie-2 Antibody
- angiopoietin-1 receptor
- CD202b antigen
- CD202b
- EC 2.7.10
- EC 2.7.10.1
- hTIE2
- p140 TEK
- soluble TIE2 variant 1
- soluble TIE2 variant 2
- TEK tyrosine kinase, endothelial
- TEK
- Tie2
- Tie-2
- TIE2CD202b
- Tunica interna endothelial cell kinase
- Tyrosine-protein kinase receptor TEK
- Tyrosine-protein kinase receptor TIE-2
- venous malformations, multiple cutaneous and mucosal
- VMCM
- VMCM1
Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]