TSH R Antibody (4C1)

Product: Cefradine

TSH R Antibody (4C1) Summary

Immunogen
External domain of human TSH receptor.
Specificity
Recognizes the human thyroid stimulating hormone (TSH) receptor (otherwise known as the thyrotropin receptor) binding to an extracellular domain.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
TSHR
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:1000-1:2000
Application Notes
This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Positive Control
TSH R Lysate (NBL1-17361)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for TSH R Antibody (4C1)

  • CHNG1
  • LGR3
  • LGR3hTSHR-I
  • MGC75129
  • seven transmembrane helix receptor
  • thyroid stimulating hormone receptor
  • Thyroid-stimulating hormone receptor
  • thyrotropin receptor
  • thyrotropin receptor-I, hTSHR-I
  • TSH R
  • TSHR
  • TSH-R

Background

Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.

PMID: 7416883