TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) Summary
| Immunogen |
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha-1/alpha-2 isotype
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| Specificity |
Specific for the ~50k TR-alpha 1 and the ~58k TR-alpha 2 protein.
|
| Predicted Species |
Mouse (100%), Primate (100%), Canine (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
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| Host |
Mouse
|
| Gene |
THRA
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The investigator should determine the optimal working dilution for a specific application.
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Reactivity Notes
It is anticipated that the antibody will react with canine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
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| Preservative |
No Preservative
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| Purity |
Protein G purified
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Alternate Names for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)
- AR7
- c-ERBA-1
- c-erbA-alpha
- EAR7
- EAR-7
- EAR-7.1/EAR-7.2
- ERBA
- ERBA1thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog)
- ERBA-related 7
- MGC000261
- MGC43240
- NR1A 1
- NR1A1
- NR1A1THRA3
- Nuclear receptor subfamily 1 group A member 1
- THRA
- THRA1ERB-T-1
- THRA2
- thyroid hormone receptor alpha
- thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a)oncogene homolog, avian)
- TR alpha
- triiodothyronine receptor
- v-ErbA1
- V-erbA-related protein 7
Background
Thyroid hormones regulate general metabolism and normal cellular growth and development. These actions are regulated by the thyroid hormone receptor (TR), a ligand-dependent transcriptional factor. At least two genes and several isoforms encode TR. Recent studies have implicated a role of TRs in thyroid hormone-induced apoptosis in larval tissues and proliferation of adult cell types (1-3).