TRIM25 Antibody Summary
| Immunogen |
Antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TRIM25. The immunogen is located within amino acids 520 – 570 of TRIM25.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TRIM25
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TRIM25 Antibody
- EC 6.3.2.19
- EC 6.3.2.n3
- EFPZ147
- Estrogen-responsive finger protein
- RING finger protein 147
- RNF147E3 ubiquitin/ISG15 ligase TRIM25
- tripartite motif containing 25
- tripartite motif-containing 25
- Tripartite motif-containing protein 25
- Ubiquitin/ISG15-conjugating enzyme TRIM25
- zinc finger protein 147 (estrogen-responsive finger protein)
- Zinc finger protein 147
- zinc finger protein-147
- ZNF147tripartite motif protein TRIM25
Background
TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.