TRAIL R3/TNFRSF10C Antibody Summary
| Immunogen |
Antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor. The immunogen is located within amino acids 90 – 140 of DcR1.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TNFRSF10C
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
DcR1 antibody can be used for detection of DcR1 by Western blot at 0.5 to 1 mg/ml. An approximate 65 kDa band can be detected.
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| Theoretical MW |
65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TRAIL R3/TNFRSF10C Antibody
- Antagonist decoy receptor for TRAIL/Apo-2L
- CD263 antigen
- CD263
- cytotoxic TRAIL receptor-3
- DcR1
- DCR1MGC149502
- Decoy receptor 1
- Decoy TRAIL receptor without death domain
- LITMGC149501
- Lymphocyte inhibitor of TRAIL
- TNFRSF10C
- TRAIL R3
- TRAIL receptor 3
- TRAIL receptor without an intracellular domain
- TRAILR3
- TRAIL-R3
- TRAILR3TNF-related apoptosis-inducing ligand receptor 3
- TRIDDCR1-TNFR
- tumor necrosis factor receptor superfamily member 10C
- tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.