TOP1MT Antibody (TOP1MT/488) [DyLight 488]

Product: Valacyclovir (hydrochloride)

TOP1MT Antibody (TOP1MT/488) [DyLight 488] Summary

Immunogen
Recombinant full-length human TOP1MT protein
Localization
Cytoplasmic (Mitochondria)
Specificity
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TOP1MT
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody shomld be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TOP1MT Antibody (TOP1MT/488) [DyLight 488]

  • mitochondrial DNA topoisomerase I
  • mitochondrial
  • topoisomerase (DNA) I, mitochondrial

PMID: 14718249