Product: Tos-Gly-Pro-Arg-ANBA-IPA
TMC6 Antibody Summary
| Immunogen |
Antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human EVER1. The immunogen is located within the first 50 amino acids of EVER1.
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| Specificity |
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TMC6
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TMC6 Antibody
- epidermodysplasia verruciformis 1
- Epidermodysplasia verruciformis protein 1
- EVER1FLJ17776
- EVIN1EV1
- expressed in activated T/LAK lymphocytes
- LAK-4P
- Protein LAK-4
- transmembrane channel-like 6
- transmembrane channel-like protein 6
Background
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.