TLR9 Antibody (1E8)

Product: GNF-3

TLR9 Antibody (1E8) Summary

Immunogen
TLR9 (AAH32713, 99 a.a. ~ 215 a.a) partial recombinant protein with GST tag.PPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVP
Specificity
TLR9 (1E8)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TLR9
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA
  • Immunocytochemistry/Immunofluorescence
Application Notes
Antibody reactive against cell lysate for Western Blot. Has also been used for immunofluoresence and ELISA.
Agonist
  • CpG oligodeoxynucleotides with negative control, TLR9 ligand

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TLR9 Antibody (1E8)

  • CD289 antigen
  • CD289
  • TLR9
  • toll-like receptor 9

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

PMID: 16431125