TL1A/TNFSF15 Antibody (VEGI/1283) Summary
| Immunogen |
Recombinant human VEGI fragment
|
| Localization |
Secreted and Cell Surface
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| Specificity |
VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
|
| Isotype |
IgG Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
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| Gene |
TNFSF15
|
| Purity |
Protein A or G purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Human Chromosome Location: 9q32
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) |
| Theoretical MW |
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
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| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for TL1A/TNFSF15 Antibody (VEGI/1283)
- MGC129934
- MGC129935
- TL1A
- TL-1A
- TL-1A/TNFSF15
- TL1Vascular endothelial cell growth inhibitor
- TNF superfamily ligand TL1A
- TNFSF15
- tumor necrosis factor (ligand) superfamily, member 15
- tumor necrosis factor ligand superfamily member 15
- vascular endothelial growth inhibitor-192A
- VEGI
- VEGI192A
- VEGITNF ligand-related molecule 1