TBK1 Antibody Summary
| Immunogen |
A synthetic peptide mapping to a region between residues 675 and the C-terminus (729) of human TANK-binding kinase 1 using the numbering given in entry NP_037386.1 (GeneID 29110).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TBK1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Western Blot. Immunohistochemistry has not been tested. *The investigator should determine the optimal working dilution for a specific application.
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|
| Theoretical MW |
84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TBK1 Antibody
- EC 2.7.11
- EC 2.7.11.1
- FLJ11330
- NAK serine/threonine-protein kinase TBK 1
- NAKserine/threonine-protein kinase TBK1
- NF-kappa-B-activating kinase
- T2K
- TANK-binding kinase 1NF-kB-activating kinase
- TBK 1
Background
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/