Syntaxin-BP1 [p Ser513] Antibody Summary
| Immunogen |
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer513 of Munc-18.
|
| Modification |
p Ser513
|
| Specificity |
Specific for the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
|
| Predicted Species |
Human (100%), Mouse (100%), Chicken (100%), Bovine (100%), Primate (100%), Xenopus (100%), Canine (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
STXBP1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
|
| Preservative |
No Preservative
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Syntaxin-BP1 [p Ser513] Antibody
- EIEE4
- FLJ37475
- hUNC18
- MUNC18-1
- NSEC1
- N-Sec1
- p67
- Protein unc-18 homolog 1
- Protein unc-18 homolog A
- rbSec1
- STXBP1
- syntaxin binding protein 1
- syntaxin-binding protein 1
- SyntaxinBP1
- Syntaxin-BP1
- UNC18
- unc18-1
- UNC18A
- unc-18A
- UNC18neuronal SEC1
Background
Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part to its ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996).