Syntaxin 6 Antibody Summary
| Immunogen |
Peptide with sequence C-QALAERKNRQA corresponding to internal region according to NP_005810.1.
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| Marker |
TGN Marker
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
STX6
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 30 kDa band observed in human lymph node lysates (calculated MW of 29.2 kDa band according to NP_005810.1). In transfected HEK293 transiently expressing human STX6 a band of approx. 30 kDa is observed. This band is not observed in the non-transfected HEK293.
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Syntaxin 6 Antibody
- STX6
- Syntaxin 6
- syntaxin-6
Background
Syntaxin 6 is a 35 kDa type II integral membrane protein with two coiled coil domains and a carboxyl terminal membrane anchor. Immunoelectron microscopy studies show that syntaxin 6 is primarily localized to the trans Golgi network (TGN), and is partially co localized with AP 1 on clathrin coated membranes. During secretory granule maturation, syntaxin 6 and MPR ligand complexes are postulated to be transferred from immature granules to endosomes by clathrin coated vesicles, as evidenced by immunoelectron microscopy. These results suggest that syntaxin 6 mediates a TGN trafficking targeting endosome.