Serpin F1/PEDF Antibody (1C4) Summary
| Immunogen |
Recombinant human PEDF (19-418 aa) purified from E. coli (NP_002606).
|
| Specificity |
Anti-human PEDF mAb, clone 1C4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PEDF protein.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SERPINF1
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4) and 10% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Serpin F1/PEDF Antibody (1C4)
- Cell proliferation-inducing gene 35 protein
- EPC-1
- EPC-1PIG35
- PEDF
- PEDFpigment epithelium-derived factor
- pigment epithelium derived factor), member 1
- proliferation-inducing protein 35
- serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin
- Serpin F1
- serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epitheliumderived factor), member 1
Background
Pigment epithelium-derived factor (PEDF) is a 50kDa glycoprotein and member of the serpin superfamily without any activity of serine protease. PEDF is an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor progression. That is, in neuronal cell, PEDF is promoting cell survival and differentiation, however, when endothelial cells are exposed to PEDF, their cell migration and proliferation are inhibited, and they undergo apoptosis.