Serpin E1/PAI-1 Antibody (3F2) Summary
| Immunogen |
SERPINE1 (NP_000593, 86 a.a. – 185 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTR
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| Localization |
Secreted
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| Specificity |
SERPINE1 – serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
SERPINE1
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against transfected lysate and recombinant protein for WB. It has been used for ELISA.
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Serpin E1/PAI-1 Antibody (3F2)
- Endothelial plasminogen activator inhibitor
- Nexin
- PAI1
- PAI-1
- PAI1PAI-1
- PAISerpin E1
- PLANH1
- PLANH1plasminogen activator inhibitor 1
- serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1
- Serpin E1
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1
Background
PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type palsminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.