Serotonin N-acetyltransferase [p Thr29] Antibody Summary
| Immunogen |
Synthetic Peptide: C(24) Q R R H T(p) L P A S(33)
|
| Modification |
p Thr29
|
| Specificity |
NB120-3439 detects phospho serotonin N-acetyltransferase (AA-NAT) from rat tissues.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
AANAT
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
WB: Detects an approx. 23 kDa protein representing phospho AA-NAT in rat pineal gland whole protein extract.
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Serotonin N-acetyltransferase [p Thr29] Antibody
- AA-NAT
- aralkylamine N-acetyltransferaseEC 2.3.1.87
- arylalkylamine N-acetyltransferase
- Serotonin acetylase
- SNATserotonin N-acetyltransferase
Background
Pineal gland Serotonin N-acetyltransferase (Arylalkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light / dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr 29 and Ser 206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation.