STEP Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human STEP / PTPN5. The exact sequence is proprietary.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PTPN5
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.28 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for STEP Antibody
- EC 3.1.3.48
- FLJ14427
- Neural-specific protein-tyrosine phosphatase
- protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
- protein-tyrosine phosphatase striatum-enriched
- STEPPTPSTEP
- Striatum-enriched protein-tyrosine phosphatase
- tyrosine-protein phosphatase non-receptor type 5
Background
Tyrosine phosphorylation plays a critical role in many physiological processes. There is a fine balance between phosphorylation caused by protein tyrosine kinases and actions of protein tyrosine phosphatases, that regulates these physiological processes. Striatal enriched phosphatase (STEP) is part of a family of protein tyrosine phosphatases enriched within the CNS and is a component of the NMDAR complex. It is expressed within dopaminoceptive neurons in the CNS and particularly enriched within the basal ganglia and related structures.STEP61 is a membrane-associated isoform and STEP46 is a cytosolic protein. In response to transient hypoxia-ischemia in the brain, STEP61 is proteolytically cleaved by calpain, thereby releasing a smaller isoform, STEP33.