STAT6 Antibody (7D3) Summary
| Immunogen |
Purified recombinant fragment of human STAT6 expressed in E. Coli.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
STAT6
|
| Purity |
Unpurified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Mouse, Rat, Primate. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for STAT6 Antibody (7D3)
- D12S1644
- EC 2.4.1.227
- EC 2.7.7.6
- IL-4 Stat
- IL-4-STAT
- signal transducer and activator of transcription 6
- signal transducer and activator of transcription 6, interleukin-4 induced
- STAT, interleukin4-induced
- STAT6
- STAT6B
- STAT6C
- transcription factor IL-4 STAT
Background
Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat-6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4).