SOS1 Antibody (SOS-01) Summary
| Immunogen |
Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein (NM_005633.3)
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| Specificity |
The SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
|
| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
SOS1
|
| Purity |
Protein A purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
WB: Use under reducing conditions. Antibody purity is > 95% (by SDS-PAGE).
|
Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for SOS1 Antibody (SOS-01)
- GF1GGF1
- GINGF
- guanine nucleotide exchange factor
- HGFhereditary, 1
- NS4
- son of sevenless homolog 1 (Drosophila)
- son of sevenless homolog 1
- SOS-1
Background
The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.