SMN Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 244 and 294 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
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| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
SMN1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for SMN Antibody
- Gemin-1
- Kugelberg-Welander disease)
- SMNC
- survival of motor neuron 1, telomeric
Background
Gemin 1 (SMN) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein.