SHP-2/PTPN11 Antibody (3F2) Summary
| Immunogen |
Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PTPN11
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Dog
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for SHP-2/PTPN11 Antibody (3F2)
- BPTP3
- EC 3.1.3.48
- MGC14433
- protein tyrosine phosphatase, non-receptor type 11
- protein tyrosine phosphatase-2
- Protein-tyrosine phosphatase 1D
- Protein-tyrosine phosphatase 2C
- PTP1D
- PTP-1D
- PTP2C
- PTP-2C
- PTP2CNS1
- PTPN11
- SHP2
- SHP-2
- SHP2CFC
- SHPTP2
- SH-PTP2
- SH-PTP2Noonan syndrome 1
- SH-PTP3
- tyrosine-protein phosphatase non-receptor type 11
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq].