SETD7/9 Antibody (s4E5) Summary
| Immunogen |
Recombinant human SET7/9 protein
|
| Specificity |
Anti-human SET7/9 mAb, clone s4E5, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SET7/9.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SETD7
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The antibody has been tested by ELISA and by Western blot analysis to assure specificity and reactivity.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4) and 10% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for SETD7/9 Antibody (s4E5)
- EC 2.1.1.43
- H3-K4-HMTase SETD7
- histone H3-lysine 4-specific methyltransferase
- histone-lysine N-methyltransferase SETD7
- KIAA1717SET domain-containing protein 7
- KMT7FLJ21193
- Lysine N-methyltransferase 7
- SET domain containing (lysine methyltransferase) 7
- SET7/9Histone H3-K4 methyltransferase SETD7
- SET7Set9
- SET9
Background
Set7/9 is a histone methyltransferase(HMTase) that transfers methyl group to Lys4 of histone H3, in complex with S-adenosyl-L-methionine(AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression.Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.