S100B Antibody (9A11B9) Summary
| Immunogen |
Purified recombinant fragment of S100B expressed in E. Coli.
|
| Marker |
Astrocyte Marker
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
S100B
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for S100B Antibody (9A11B9)
- beta (neural)
- NEF
- S100 beta
- S100 calcium binding protein B
- S100 calcium-binding protein B
- S100 calcium-binding protein, beta (neural)
- S-100 calcium-binding protein, beta chain, 10protein S100-B
- S-100 protein beta chain
- S-100 protein subunit beta
- S100
- S100B
- S100beta
Background
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwanns cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin, and in Langerhans cells in the skin. The anti S-100 monoclonal antibody gives positive staining of glial and ependymal cells of the brain, Schwann cells of the peripheral nervous system, melanocytes and Langerhans cells of the skin, and interdigitating reticulum cells in lymph nodes. Benign and malignant melanocytic tumors stain positively with the S-100 antibody. Anti-S-100 recognizes the 21-24kDa proteins identified as the A and B subunits of the S-100 protein.