S100A8 Antibody (7C12/4) Summary
| Immunogen |
Recombinant human S100A8
|
| Isotype |
IgM
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
S100A8
|
| Purity |
IgM purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
IgM purified
|
Notes
Positive control(s): Neutrophil lysate (from spleen).
Alternate Names for S100A8 Antibody (7C12/4)
- 60B8AG
- CAGACP-10
- Calgranulin A
- calgranulin-A
- Calprotectin L1L subunit
- CFAG
- CFAGL1Ag
- CGLA
- Cystic fibrosis antigen
- Leukocyte L1 complex light chain
- MA387
- MIF
- Migration inhibitory factor-related protein 8
- MRP8
- MRP-8
- MRP8S100 calcium binding protein A8 (calgranulin A)
- NIF
- P8
- protein S100-A8
- S100 calcium binding protein A8
- S100 calcium-binding protein A8 (calgranulin A)
- S100 calcium-binding protein A8
- S100A8
- Urinary stone protein band A
Background
The monoclonal antibody 7C12/4 recognizes an epitope on the S100A8 (MRP-8) protein. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.