Recombinant Human FUS Protein

Product: BOC-D-FMK

Recombinant Human FUS Protein Summary

Description
A full-length protein with an N-terminal His tag and corresponding to amino acids 1 – 526 of FUS.

Source: E. coli

Amino Acid Sequence: MGSSHHHHHHHHGQNLYFQGAMSASNDYTQQATQSYGA YPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSS YSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSY SQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGG GGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGG SGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEP RGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQD NSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLY TDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSF ATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGR GGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQC KAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGR GGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY

Protein/Peptide Type
Full Length Recombinant Protein
Gene
FUS

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
25 mM Tris pH 8.0, 250 mM NaCl, 8 M Urea, 1 mM DTT
Concentration
0.5 mg/ml

Notes

This FUS Protein has a Purity >95%. This product was tested in Western Blot using NB100-562. The antibody was used to detect 60ng on the western blot.

Alternate Names for Recombinant Human FUS Protein

  • 75 kDa DNA-pairing protein
  • ALS6
  • amyotrophic lateral sclerosis 6
  • FUS1
  • fused in sarcoma
  • fusion (involved in t(12;16) in malignant liposarcoma)
  • fusion gene in myxoid liposarcoma
  • fusion, derived from t(12;16) malignant liposarcoma
  • fus-like protein
  • heterogeneous nuclear ribonucleoprotein P2
  • HNRNPP2
  • Oncogene FUS
  • Oncogene TLS
  • POMP75
  • RNA-binding protein FUS
  • TLShnRNP-P2
  • Translocated in liposarcoma protein

Background

Tyrosine FUS is a nucleic acid-binding protein whose N-terminal half functions as a transcriptional activator domain in fusion oncoproteins found in human leukemias and liposarcomas. FUS has been reported to be associated with the nuclear matrix and has been implicated in transcription, pre-mRNA splicing processes, spliceosome assembly, and promoting undifferentiated endothelial cells. Human FUS with an N-terminal His tag expressed in E. coli and purified by conventional chromatography.

PMID: 22473614