Rat IL-17/IL-17A ELISA Kit Summary
| Standard Curve Range |
1.6 – 100 pg/mL
|
| Sensitivity |
1.0 pg/mL
|
| Sample Volume |
50 uL
|
| Kit Type |
ELISA Kit
|
| Gene |
IL17A
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Applications/Dilutions
| Application Notes |
The rat IL-17A ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of rat IL-17A.
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Packaging, Storage & Formulations
| Storage |
Storage of components varies. See protocol for specific instructions.
|
Kit Components
| Components |
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Alternate Names for Rat IL-17/IL-17A ELISA Kit
- CTLA-8
- CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
- Cytotoxic T-lymphocyte-associated antigen 8
- IL17
- IL-17
- IL17A
- IL-17A
- IL-17Acytotoxic T-lymphocyte-associated protein 8
- IL-17CTLA-8
- IL17interleukin-17A
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin 17A
Background
IL-17A, a homodimeric cytokine of about 32 kDa, is largely produced by activated memory T lymphocytes, but stimulates innate immunity and host defense. IL-17A and IL-17F both mobilize neutrophils partly through granulopoeisis and CXC chemokine induction, as well as increased survival locally. IL-17A and IL-17F production by T lymphocytes is regulated by IL-23 independent of T cell receptor activation. The Th1 and Th2 cell classification has until recently provided the framework for understanding CD4+ T cell biology and the interplay between innate and adaptive immunity. The Th17 lineage produces interleukin 17, which is highly proinflammatory and induces severe autoimmunity. Increased levels of IL-17 have been associated with several conditions, including airway inflammation, rheumatoid arthritis, intraperitoneal abscesses and adhesions, inflammatory bowel disease, allograft rejection, psoriasis, cancer and multiple sclerosis.