RanBP3 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to residues M(1) A D L A N E E K P A L A(13) C of human RanBP3.
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| Specificity |
Detects Ran binding protein 3 (RanBP 3) from human and rat cells.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
RANBP3
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Detects an approx. 60 kDa protein representing RanBP 3 from HeLa cell extracts. IF: Staining of RanBP 3 in NRK cells results in diffuse nuclear staining.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.05% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for RanBP3 Antibody
- DKFZp586I1520
- RAN binding protein 3
- ran-binding protein 3
- RAN-binding protein-3
- RanBP3
Background
Transport of macromolecules into and out of the nucleus occurs through nuclear pore complexes (NPC). This energy-dependent process involves nucleoporins at the NPC, associated transport proteins and GTP. The GTPase Ran is a small protein that belongs to the RAS protein superfamily and is found associated with the nuclear membrane. Ran GTPase is essential for mRNA processing, nuclear transport, cell cycle control, mitotic spindle assembly, and postmitotic nuclear re-assembly and nuclear architecture maintenance. Ran binding proteins (RanBPs) belong to a family of proteins that bind Ran GTPase and help to stimulate its GTPase activity. Members of the RanBP family show weak similarity to importin beta, a protein involved in the transport of proteins to the nuclear membrane. RanBP3 functions as a cofactor for CRM1-mediated nuclear export and stimulates export by enhancing the affinity of CRM1 for RanGTP and substrate.